DMTMM for Oligonucleotide Chemistry
Clean aqueous coupling for modification steps in oligo synthesis
For process chemists working on oligonucleotide modifications and conjugation steps
Your Challenge. Our Answer.
We understand the specific problems you face — and we built solutions for each one.
The Problem
Post-synthetic modification and conjugation steps often require aqueous-compatible coupling chemistry
Mironova’s Answer
DMTMM·Cl activates carboxylic acids directly in water at neutral pH — ideal for oligonucleotide modification steps
The Problem
EDC/NHS coupling in aqueous conditions has poor reproducibility and low yields for nucleic acid conjugates
Mironova’s Answer
DMTMM’s stable activation intermediate and broader pH tolerance offer improved reproducibility for aqueous conjugation
Published Evidence
Key findings from peer-reviewed literature relevant to your application.
Aqueous Activation Stability
DMTMM forms a stable acyloxytriazine intermediate in water, unlike EDC’s transient O-acylisourea that rapidly hydrolyzes.
Kunishima et al., Tetrahedron 1999
On-DNA Amidation Performance
DMTMM·PF₆ achieved higher conversion than HATU for on-DNA amidation, demonstrating nucleic acid compatibility.
Hosozawa et al., Bioorg. Med. Chem. Lett. 2024
Recommended Products
The specific products from our catalog that match your application.
Oligonucleotide Modification Conditions
- Use DMTMM·Cl for fully aqueous conjugation steps (pH 6–8)
- Use DMTMM·PF₆ for organic/mixed-solvent modification steps
- 1.0–20 eq reagent depending on substrate and coupling efficiency required
- RT to 40 °C, 2–16 h reaction time
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Related Resources
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