Multi-Target Hair Growth Actives
A 6-active portfolio spanning follicular signaling, collagen modulation, and antioxidant support
For cosmetic formulators developing premium hair growth and scalp health products
Your Challenge. Our Answer.
We understand the specific problems you face — and we built solutions for each one.
The Problem
Reliance on a single active (minoxidil) limits formulation differentiation and creates IP constraints for premium positioning
Mironova’s Answer
Mironova offers a multi-target portfolio: Kopyrrol Aqua (PDPO), Kopexil Aqua (DPO), plus cosmetic peptides — each addressing different follicular pathways
The Problem
Many hair growth actives are poorly water-soluble, requiring organic co-solvents that irritate sensitive scalps
Mironova’s Answer
Both Kopyrrol Aqua and Kopexil Aqua are freely water-soluble OTZ salt forms — clean aqueous formulation without propylene glycol or ethanol
The Problem
Regulatory pressure on prostaglandin analogues (EU SCCS opinion, Health Canada hotlist) creates market need for non-PG alternatives
Mironova’s Answer
Our non-prostaglandin actives provide options for regulated markets where PG analogues face restrictions or consumer concerns
The Problem
Ingredient suppliers offer single actives, forcing formulators to manage multiple vendor relationships for a multi-active approach
Mironova’s Answer
Single-source supply for multiple mechanistically distinct actives, simplifying procurement and enabling coordinated formulation support
Published Evidence
Key findings from peer-reviewed literature relevant to your application.
Collagen Maturation Modulation (DPO)
Aminexil (DPO) retains strong inhibition of lysyl hydroxylase mRNA expression in vitro, targeting the collagen maturation pathway around hair follicles.
Mahé et al., Skin Pharmacology 1996
K₊ATP Channels in Hair Follicles
Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which responds to minoxidil-class openers.
Shorter et al., FASEB Journal 2008
Perifollicular Fibrosis in AGA
Collagenous sheath thickening and inflammatory infiltrates are documented around miniaturizing follicles — a modifiable axis for hair growth formulations.
Jaworsky et al., 1992; Li et al., 2025
OTZ as Intracellular Cysteine Prodrug
OTZ is converted to cysteine by 5-oxoprolinase, supporting glutathione biosynthesis. Provides antioxidant support in the formulation’s delivery system.
Williamson & Meister, PNAS 1981
Recommended Products
The specific products from our catalog that match your application.
Formulation Guidelines
- Diaminopyrimidine actives: 0.2–1.5% (w/w); cosmetic peptides: 1–50 ppm
- Small-molecule actives are freely water-soluble — add directly to aqueous phase
- Lipopeptides may require slight warming (40°C) for dissolution
- Compatible with common cosmetic emulsion systems
- Stable at pH 3.0–7.0 in finished formulations
- Multi-mechanism approach: channel-opening (PDPO/DPO), ECM support (peptides), antioxidant (OTZ)
Request Technical Data
Get product specifications, CoA samples, and pricing for your evaluation.
Request Ingredient Samples
Receive evaluation samples of our hair growth actives — small-molecule and cosmetic peptide options — with technical data sheets and formulation guidance.
Or call us at +1 (973) 244-0393
Related Resources
Technical data, product specifications, and application guidance.