DMTMM hexafluorophosphate (PF₆⁻)

Overview

DMTMM·PF₆ (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium hexafluorophosphate) is a high-performance coupling reagent for efficient amide and ester bond formation. It combines the well-established reactivity of the DMTMM triazine core with the enhanced stability and low hygroscopicity of the hexafluorophosphate (PF₆⁻) counterion.

DMTMM·PF₆ is particularly well suited for demanding peptide and small-molecule coupling reactions where improved shelf stability, excellent solubility in polar aprotic solvents, and clean reaction profiles are required.

Key Advantages

High Coupling Efficiency

Rapid activation of carboxylic acids enables efficient amide bond formation with primary and secondary amines, including sterically hindered substrates.

Low Epimerization

Mild activation conditions help suppress racemization, making DMTMM·PF₆ suitable for stereochemically sensitive peptide and chiral API synthesis.

Enhanced Stability & Low Hygroscopicity

The PF₆⁻ counterion provides improved moisture resistance and shelf stability compared with more hygroscopic salt forms.

Excellent Solubility in Polar Aprotic Solvents

Highly soluble in DMF, NMP, DMSO, and related media commonly used in peptide and pharmaceutical synthesis.

Clean Reaction Profiles

Typically produces easily separable byproducts, simplifying purification and improving overall process robustness.

Applications

Peptide Synthesis

• Solid-phase and solution-phase peptide coupling
• Challenging couplings involving sterically hindered or β-branched amino acids
• Late-stage peptide assembly where reproducibility and low epimerization are critical

Amide Bond Formation in Small Molecules

• Pharmaceutical intermediates and APIs
• Medicinal chemistry and SAR library synthesis

Fragment Condensation

• Segment coupling in convergent peptide synthesis
• High-efficiency bond formation with minimal side reactions

Research & Development

• Development of new peptide-based therapeutics, linkers, and bioactive compounds

Available Forms

We supply DMTMM·PF₆ as a standalone coupling reagent in:

• Research-scale quantities
• Process development and pilot-scale batches
• Commercial multi-kilogram quantities

Custom specifications (purity targets, moisture limits, packaging under inert atmosphere) are available upon request.

Technical Information

DMTMM·PF₆ is manufactured under controlled conditions with comprehensive analytical characterization to ensure consistent performance:

• Typical purity: ≥99% (HPLC or qNMR, per specification)
• Identity confirmation by ¹H / ¹³C NMR and MS
• Water content by Karl Fischer titration
• Counterion verification as required

Full analytical data are provided on the Certificate of Analysis (CoA).

Quality Assurance

Each batch is released in accordance with a documented quality system and includes:

• Purity and identity confirmation
• Moisture content determination
• Appearance and solubility assessment
• Batch-to-batch consistency review

Additional documentation for regulated or pharmaceutical applications can be provided upon request.

Important Safety Information

⚠️ Warning: DMTMM·PF₆ is a reactive coupling reagent intended for use only by trained professionals in laboratory or manufacturing environments. Handle with appropriate PPE (gloves, safety glasses, lab coat) and in a well-ventilated fume hood. Avoid exposure to moisture and incompatible reagents. Refer to the SDS for complete safety, handling, and disposal information.