Mironova Labs

L-Ergothioneine for Skincare

A uniquely transporter-targeted antioxidant — actively accumulated via OCTN1

For personal care formulators developing anti-aging, photoprotective, and sensitive-skin products

Request Ingredient Samples Ergothioneine Science Hub

OCTN1

Dedicated Transporter

≥99%

Purity (HPLC)

Synthetic

Defined Route

mtDNA

Protection Published

Supported by peer-reviewed research·Dedicated skin transporter (OCTN1)·US-manufactured·Formulation-stable·Peer-reviewed

Ergothioneine is actively accumulated by skin cells via the OCTN1/SLC22A4 transporter, not passively diffused. Published studies demonstrate transporter-dependent protection against UV-induced mtDNA damage. Mironova’s synthetic ergothioneine (≥99% purity) offers consistent performance for topical formulations and dual-use (topical + oral) product lines.

Ergothioneine Science Hub Ergothioneine Products

Challenges & Solutions

Your Challenge. Our Answer.

We understand the specific problems you face — and we built solutions for each one.

The Problem

Most topical antioxidants (vitamin C, vitamin E, CoQ10) rely on passive diffusion and have limited cellular uptake

Mironova’s Answer

Skin cells express OCTN1, a dedicated EGT transporter — active cellular uptake means EGT accumulates where protection is needed

The Problem

UV-induced oxidative damage degrades extracellular matrix components, accelerating visible skin aging

Mironova’s Answer

EGT has been shown in cell models to reduce markers of UV-induced oxidative damage in dermal fibroblasts and keratinocytes, supporting ECM integrity

The Problem

Formulators need antioxidants with demonstrated stability in cosmetic matrices — many actives degrade during shelf life

Mironova’s Answer

EGT is significantly more stable than glutathione and L-cysteine at physiological pH, with excellent formulation compatibility

Published Research

Published Evidence

Key findings from peer-reviewed literature relevant to your application.

Dedicated Skin Transporter

Skin is a primary target tissue with high OCTN1 (EGT transporter) expression. EGT is actively accumulated, not passively absorbed.

Oblong, J. Cosmet. Dermatol. 2019

UV Photoprotection

EGT significantly reduced UV-induced oxidative stress, DNA damage, and apoptosis in epithelial cell models, supporting its role as a photoprotective ingredient.

Torregrossa et al., Exp. Eye Res. 2019; Oblong, J. Cosmet. Dermatol. 2019

Mitochondrial Protection

EGT preserved mitochondrial membrane potential and reduced ROS accumulation in cellular aging models.

Kameda et al., Free Radic. Biol. Med. 2020

Product Catalog

Cosmetic Formulation Notes

EGT typical use level: 0.01–0.5% in finished formulations. Peptide actives: 1–50 ppm — compatible with EGT in the same aqueous phase.

Water-soluble — add to aqueous phase.

pH stability: 3.0–8.0.

Compatible with common cosmetic emulsion systems.

EGT is complementary with vitamin C (different radical-scavenging mechanisms).

For full mechanism data, transporter science, and peer-reviewed studies, please visit our Ergothioneine Science Hub.

Why Mironova

Your Advantage with Mironova

Transporter-Targeted Delivery

Skin cells express the OCTN1/SLC22A4 transporter that actively accumulates ergothioneine. This is not passive diffusion — it is selective uptake, differentiating ergothioneine from commodity antioxidants.

Published UV Protection Data

Published studies demonstrate ergothioneine protects against mtDNA common deletion in UV-exposed fibroblasts via transporter-dependent mechanisms. This is peer-reviewed mechanistic data, not marketing claims.

Synthetic Consistency

≥99% purity via defined synthetic route. No batch variability from fermentation or extraction. Consistent performance in formulation stability studies.

Cosmetic + Supplement Dual Use

Same ingredient, dual positioning. Ergothioneine works as a topical cosmetic active and an oral supplement ingredient — enabling “inside-out” beauty product lines.

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Get product specifications, CoA samples, and pricing for your evaluation.

FAQ

Frequently Asked Questions

Common technical questions about this product line, answered by our scientific team.

No. Ergothioneine is selectively accumulated via the dedicated OCTN1/SLC22A4 membrane transporter, concentrated in tissues under oxidative stress. It scavenges hydroxyl radicals, HOCl, and peroxynitrite. The 2025 Cell Metabolism study links it to H₂S/persulfidation signaling and NAD⁺ metabolism — biology that goes well beyond generic radical scavenging.

Published studies show transporter-dependent protection against mtDNA damage in UV-exposed fibroblasts. Topical claims should be substantiated with your own formulation testing. Avoid unsubstantiated performance comparisons (e.g., “3× vitamin C”) without controlled data in your specific formulation.

Typical topical use levels and formulation pH compatibility should be discussed with our technical team based on your specific product type and target claims. Contact us for formulation guidance documentation.

Ergothioneine is compatible with common cosmetic actives including peptides, vitamin C derivatives, and hyaluronic acid. pH stability and active interactions should be validated in your formulation. We provide compatibility guidance upon request.