L-Ergothioneine for Skincare
Nature’s most efficient antioxidant — with a dedicated skin transporter
For personal care formulators developing anti-aging, photoprotective, and sensitive-skin products
Your Challenge. Our Answer.
We understand the specific problems you face — and we built solutions for each one.
The Problem
Most topical antioxidants (vitamin C, vitamin E, CoQ10) rely on passive diffusion and have limited cellular uptake
Mironova’s Answer
Skin cells express OCTN1, a dedicated EGT transporter — active cellular uptake means EGT accumulates where protection is needed
The Problem
UV-induced oxidative damage degrades extracellular matrix components, accelerating visible skin aging
Mironova’s Answer
EGT protects dermal fibroblasts and keratinocytes from UV-induced oxidative damage and prevents ECM degradation
The Problem
Formulators need antioxidants with demonstrated stability in cosmetic matrices — many actives degrade during shelf life
Mironova’s Answer
EGT is significantly more stable than glutathione and L-cysteine at physiological pH, with excellent formulation compatibility
Published Evidence
Key findings from peer-reviewed literature relevant to your application.
Dedicated Skin Transporter
Skin is a primary target tissue with high OCTN1 (EGT transporter) expression. EGT is actively accumulated, not passively absorbed.
Oblong, J. Cosmet. Dermatol. 2019
UV Photoprotection
EGT significantly reduced UV-induced oxidative stress, DNA damage, and apoptosis in epithelial cell models, supporting its role as a photoprotective ingredient.
Torregrossa et al., Exp. Eye Res. 2019; Oblong, J. Cosmet. Dermatol. 2019
Mitochondrial Protection
EGT preserved mitochondrial membrane potential and reduced ROS accumulation in cellular aging models.
Kameda et al., Free Radic. Biol. Med. 2020
Recommended Products
The specific products from our catalog that match your application.
Cosmetic Formulation Notes
- Typical use level: 0.01–0.5% in finished formulations
- Water-soluble — add to aqueous phase
- pH stability: 3.0–8.0
- Compatible with common cosmetic emulsion systems
- Synergistic with vitamin C (complementary radical-scavenging mechanisms)
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Related Resources
Technical data, product specifications, and application guidance.