DMTMM chloride (Cl⁻)

Overview

DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride) is a highly efficient triazine-based condensing reagent that has become the reagent of choice for amide bond formation under mild conditions. Unlike traditional coupling reagents, DMTMM maintains excellent activity in aqueous and protic solvents, making it indispensable for applications where water compatibility is essential.

Key Advantages

DMTMM offers several distinct advantages over conventional coupling agents:

• Aqueous Compatibility: Remains active in water, alcohols, and mixed aqueous-organic systems
• No Additives Required: Functions efficiently without additional bases or activation agents
• Easy Work-up: Water-soluble byproducts enable simple purification procedures
• Low Racemization: Minimal epimerization during amino acid coupling
• Broad Substrate Scope: Suitable for coupling sterically hindered substrates

Applications

Peptide Synthesis

DMTMM is highly suitable for coupling hindered amino acids with minimal racemization. It is particularly valuable in solid-phase and solution-phase peptide synthesis.

Polysaccharide Modification

Ideal for modifying hyaluronic acid, alginate, chitosan, and other biopolymers in aqueous media. Widely used in hydrogel preparation and tissue engineering applications.

Surface Functionalization

Used to attach biomolecules to surfaces for biosensors, medical devices, and diagnostic platforms.

Bioconjugation

Enables efficient conjugation of proteins, peptides, and small molecules for therapeutic delivery and imaging applications.

Technical Information

DMTMM is produced through controlled synthesis with rigorous quality control. Our high-purity material ensures consistent performance in demanding synthetic applications.

Quality Assurance

• Purity determination by HPLC (≥99.0%)
• Identity confirmation by NMR and MS
• Moisture content analysis
• Batch-to-batch consistency testing

Manufacturing Capabilities

We offer DMTMM from research quantities (100g) to commercial scale (50kg+) with consistent quality. Custom packaging and labeling available upon request.

Important Safety Information

⚠️ Warning: This is a reactive chemical reagent intended for laboratory and manufacturing use only by qualified professionals. Handle with appropriate PPE including gloves, safety glasses, and lab coat. Avoid contact with skin and eyes. Refer to SDS for complete safety information.