L-Ergothioneine for Dietary Supplements
The "longevity vitamin" — GRAS (self-affirmed), EU Novel Food authorized
For supplement brands and formulators developing longevity, cognitive health, and antioxidant products
GRAS
FDA Status (Self-Affirmed)
≥99%
Purity (HPLC)
30 mg/day
EU Supplement Ceiling
21 yr
Epidemiology Cohort
L-Ergothioneine is a naturally occurring amino acid uniquely accumulated via the dedicated OCTN1/SLC22A4 transporter — distinguishing it from passively distributed antioxidants. Mironova produces synthetic ergothioneine at ≥99% purity with GRAS (self-affirmed) and EU Novel Food authorization, providing consistent quality for supplement formulations.
Challenges & Solutions
Your Challenge. Our Answer.
We understand the specific problems you face — and we built solutions for each one.
The Problem
Consumer demand for science-backed longevity ingredients is growing, but most antioxidants have undifferentiated positioning
Mironova’s Answer
L-Ergothioneine has a dedicated transporter (OCTN1) — it’s actively accumulated in tissues, unlike passively absorbed antioxidants. The “longevity vitamin” positioning is peer-reviewed.
The Problem
Regulatory pathway for novel ingredients is complex — brands need ingredients with established safety dossiers
Mironova’s Answer
EGT has GRAS status (self-affirmed) and EU Novel Food authorization (EFSA, up to 30 mg/day). Clear regulatory pathway.
The Problem
Dietary intake of EGT is very low in Western diets (mushrooms are the primary source), creating a supplementation opportunity
Mironova’s Answer
Estimated US dietary intake is far below levels associated with benefit in epidemiological studies — strong rationale for supplementation
Published Research
Published Evidence
Key findings from peer-reviewed literature relevant to your application.
Reduced Mortality & CV Risk
Prospective study (n = 3,236): higher plasma EGT independently associated with reduced all-cause mortality and lower cardiovascular events.
Smith et al., Heart 2020
"Longevity Vitamin" Hypothesis
EGT proposed as a “longevity vitamin” — insufficient dietary EGT may accelerate aging-associated damage.
Ames, PNAS 2018
Cognitive Decline Association
Plasma EGT levels decline significantly beyond age 60 and are lower in individuals with mild cognitive impairment.
Cheah et al., Biochem. Biophys. Res. Commun. 2016
Longitudinal Cognitive Cohort
In 470 memory clinic participants followed up to 5 years, lower baseline plasma EGT was associated with faster cognitive decline across multiple domains.
Cheah et al., Free Radic. Biol. Med. 2022
16-Week RCT in Older Adults
RCT (n=147, ages 55–79) testing 10 and 25 mg daily EGT. Clear dose-dependent pharmacokinetics. Signals in subjective memory and sleep initiation at 25 mg. No adverse events.
Halliwell, Cheah et al., Clinical Nutrition 2024
GRAS (Self-Affirmed) Status
L-Ergothioneine has established GRAS status for specified food uses in the US, with EU Novel Food authorization under Regulation (EU) 2018/462.
GRAS Self-Affirmation Framework; EU Reg. 2018/462
Market Context
Ergothioneine Is Emerging as a Longevity Ingredient
Bruce Ames’ “longevity vitamins” framework positioned ergothioneine alongside PQQ and taurine as compounds essential for long-term health. A 21-year epidemiology cohort (Malmö Diet and Cancer, ~3,236 subjects) found ergothioneine most strongly associated with a healthier dietary pattern, with lower coronary disease and all-cause mortality per SD increase. A 2025 Cell Metabolism study linked ergothioneine to H₂S/persulfidation signaling and higher NAD⁺ in aged muscle tissue. These are observational and mechanistic findings — not proof that supplementation treats any disease.
Malmö Diet and Cancer Study; Ames (2018); Cell Metabolism (2025)
~3,236
Cohort participants
2025
Cell Metabolism study
GRAS
FDA Self-Affirmed
Product Catalog
Recommended Products
The specific products from our catalog that match your application.
Application Notes
Supplement Formulation Notes
Why Mironova
Your Advantage with Mironova
Synthetic, Not Fermentation
Produced via defined synthetic route with ≥99% purity (HPLC). Consistent composition batch to batch — no variability from biological production systems.
GRAS + EU Novel Food
Self-affirmed GRAS status for food and supplement use in the US. EU Novel Food authorized (EFSA opinion) with defined maximum levels: 30 mg/day for adult supplements.
Transporter-Targeted Biology
Ergothioneine is actively accumulated via the dedicated OCTN1/SLC22A4 transporter — not passively distributed. This selective uptake distinguishes it from generic antioxidants.
US Manufacturing with Documentation
Full analytical documentation suitable for supplement product dossiers. Produced in Fairfield, NJ with raw material traceability.
Request Technical Data
Get product specifications, CoA samples, and pricing for your evaluation.
FAQ
Frequently Asked Questions
Common technical questions about this product line, answered by our scientific team.
Request Ingredient Samples
Receive evaluation-grade L-Ergothioneine with technical data sheet and regulatory documentation.
Or call us at +1 (973) 244-0393
Related Resources
Technical data, product specifications, and application guidance.