DMTMM for Biomaterials & Polymer Chemistry
Higher substitution than EDC/NHS, no pH gymnastics
For materials scientists and polymer chemists functionalizing hyaluronan, cellulose, alginate, and hydrogel systems
Your Challenge. Our Answer.
We understand the specific problems you face — and we built solutions for each one.
The Problem
EDC/NHS leaves irreversible N-acylurea residues on modified polymer surfaces — a product liability for implantable materials
Mironova’s Answer
DMTMM produces only water-soluble byproducts. Clean surfaces after simple dialysis — no persistent coupling-agent contamination.
The Problem
EDC requires acidic pH (3.5–4.5) for activation but amine nucleophilicity is optimal at neutral pH — a fundamental tension
Mironova’s Answer
DMTMM activates carboxylic acids effectively at pH 6–8, aligning activation and nucleophile reactivity in a single step
Published Evidence
Key findings from peer-reviewed literature relevant to your application.
HA Functionalization Superiority
DMTMM produced higher substitution than EDC/NHS across all tested substrates (small amines, proteins, drugs) on hyaluronan at matched feed ratios.
D’Este et al., Carbohydrate Polymers 2014
No Surface Contamination
EDC/NHS left persistent N-acylurea on TEMPO-oxidized cellulose nanofibrils. DMTMM avoided this.
Kumar et al., Communications Chemistry 2023
Recommended Products
The specific products from our catalog that match your application.
Polymer Functionalization Conditions
- Solvent: Water or aqueous buffer
- Equivalents: 2.0–10.0 eq relative to surface carboxyl groups
- Temperature: Room temperature
- Time: 4–24 h
- Cleanup: simple dialysis removes all byproducts
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Related Resources
Technical data, product specifications, and application guidance.