Myristoyl Tetrapeptide-12

Overview

Myristoyl Tetrapeptide-12 is a synthetic lipopeptide in which myristic acid (C14 fatty acid) is conjugated to a four-amino-acid sequence that partitions into the follicular lipid environment to support scalp health. The myristoyl group anchors the peptide in the follicular lipid environment and enhances local delivery relative to unmodified sequences.

Mironova Labs supplies Myristoyl Tetrapeptide-12 as a research-grade cosmetic active, produced in partnership with a specialized peptide synthesis facility, for use in scalp health serums, hair fortification treatments, and multi-active hair enhancement formulations.

Mechanism of Action

• Follicular support — The tetrapeptide sequence supports the follicular environment that enables healthy follicle cycling.
• Structural maintenance — May support the structural environment surrounding the hair follicle.
• Lipid-mediated penetration — The C14 myristoyl chain enables the peptide to partition into follicular sebum and lipid channels, improving bioavailability at the follicular target site.
• Scalp health — As a complement to growth-focused actives, Myristoyl Tetrapeptide-12 contributes to overall follicular environment quality, which underpins long-term hair density and fiber robustness.

Formulation Notes

• Functional at 1–20 ppm; recommended starting point is 5 ppm for leave-on scalp serums
• Water soluble; compatible with aqueous serum, tonic, and emulsion vehicles
• Stable at pH 4.5–7.5
• Strong complement to Myristoyl Hexapeptide-16 (follicle support) and Biotinoyl Tripeptide-1 (follicular environment) in comprehensive multi-peptide hair serums
• Compatible with Kopyrrol Aqua and Kopexil Aqua for small-molecule + peptide combination formulas

Regulatory Information

Myristoyl Tetrapeptide-12 is listed in INCI as MYRISTOYL TETRAPEPTIDE-12. Formulators are responsible for compliance with applicable cosmetic regulations in their markets.