Tetrafluoroborate Salts (BF₄⁻)
Also known as: BF4, Tetrafluoroborate anion, Fluoroborate
High-purity tetrafluoroborate coupling reagent salts for peptide synthesis and organic chemistry. Cost-effective alternative to hexafluorophosphate with excellent coupling efficiency.
Product Information
CAS Number
14874-70-5
Molecular Formula
BF₄⁻
Molecular Weight
86.80 g/mol (anion)
Prices and lead time available upon request
Product Documents
Safety Data Sheet (SDS)
Available on request
Product Specification
Available on request
Certificate of Analysis
Provided with order
Overview
Tetrafluoroborate (BF₄⁻) salts serve as widely-used counterions in peptide coupling chemistry. As the counterion in popular reagents like TBTU and other uronium coupling agents, tetrafluoroborate offers an excellent balance of performance, cost-effectiveness, and ease of handling.
Key Advantages
Tetrafluoroborate-based coupling reagents provide several benefits:
- Cost-Effective: More economical than hexafluorophosphate alternatives
- High Coupling Efficiency: Excellent yields in standard coupling conditions
- Good Solubility: Soluble in DMF, DMSO, water, and other polar solvents
- Established Track Record: Decades of proven performance in peptide synthesis
- Environmental Considerations: Smaller molecular weight reduces waste burden
Applications
Routine Peptide Synthesis
Tetrafluoroborate coupling reagents are workhorses in peptide synthesis laboratories, offering reliable performance for standard amino acid couplings.
Large-Scale Manufacturing
Preferred in many industrial applications where cost considerations are important without sacrificing quality.
Solid-Phase Synthesis
Widely compatible with standard SPPS protocols and resin systems.
Academic Research
Popular choice in research laboratories due to good performance-to-cost ratio.
Available Forms
We supply tetrafluoroborate as various coupling reagent formulations:
- Custom salt preparations available
- Research to commercial quantities
- Various counterion combinations
Technical Information
Our tetrafluoroborate salts are produced with strict quality control to ensure consistent performance in peptide synthesis applications.
Quality Assurance
- Purity determination by HPLC (≥99.0%)
- Water content analysis by Karl Fischer
- Identity confirmation by ¹⁹F NMR and ¹¹B NMR
- Counterion analysis
Comparison with Hexafluorophosphate
| Property | BF₄⁻ | PF₆⁻ | |----------|------|------| | Cost | Lower | Higher | | Stability | Good | Excellent | | Solubility | Higher (water-soluble) | Moderate | | Hygroscopicity | Slightly higher | Lower |
Both counterions provide excellent coupling efficiency. The choice depends on specific application requirements, scale, and budget considerations.
Manufacturing Capabilities
We offer tetrafluoroborate-based coupling agents from research quantities to commercial scale with consistent quality. Custom formulations and salt forms available upon request.
Important Safety Information
⚠️ Warning: This is a reactive chemical reagent intended for laboratory and manufacturing use only by qualified professionals. Handle with appropriate PPE including gloves, safety glasses, and lab coat. Some formulations may release HF upon decomposition; ensure proper ventilation. Refer to SDS for complete safety information.
Questions About This Product?
Our technical team is available to discuss specifications, custom formulations, and bulk pricing.