Hexafluorophosphate Salts (PF₆⁻)

Overview

Hexafluorophosphate (PF₆⁻) salts are essential components in modern peptide coupling chemistry. As counterions for popular uronium and phosphonium coupling reagents like HATU, HBTU, and PyBOP, hexafluorophosphate salts provide excellent solubility characteristics and stability profiles that make them ideal for demanding synthetic applications.

Key Advantages

Hexafluorophosphate-based coupling reagents offer several benefits:

• High Stability: Non-nucleophilic anion provides excellent shelf stability
• Good Solubility: Excellent solubility in DMF, NMP, and other polar aprotic solvents
• Clean Reactions: Minimal side reactions due to inert counterion
• Versatility: Compatible with wide range of amino acids and peptide sequences
• Low Hygroscopicity: Less moisture-sensitive than tetrafluoroborate analogs

Applications

Peptide Synthesis

Hexafluorophosphate coupling reagents are the gold standard in solid-phase peptide synthesis (SPPS), particularly for difficult couplings involving sterically hindered or β-branched amino acids.

Fragment Condensation

Essential for segment coupling in convergent peptide synthesis strategies where high efficiency and low epimerization are critical.

Pharmaceutical Manufacturing

Widely used in commercial peptide API production due to consistent quality and reliable performance.

Research & Development

The preferred choice for developing new peptide-based therapeutics and bioactive compounds.

Available Forms

We supply hexafluorophosphate as various coupling reagent formulations:

• Custom salt preparations available
• Research to commercial quantities
• Various counterion combinations

Technical Information

Our hexafluorophosphate salts are manufactured under controlled conditions with rigorous quality control to ensure optimal performance in peptide synthesis applications.

Quality Assurance

• Purity determination by HPLC (≥99.0%)
• Water content analysis by Karl Fischer
• Identity confirmation by ¹⁹F NMR
• Counterion analysis

Manufacturing Capabilities

We offer hexafluorophosphate-based coupling agents from research quantities to commercial scale with consistent quality. Custom formulations and salt forms available upon request.

Important Safety Information

⚠️ Warning: This is a reactive chemical reagent intended for laboratory and manufacturing use only by qualified professionals. Handle with appropriate PPE including gloves, safety glasses, and lab coat. Some formulations may be moisture-sensitive. Refer to SDS for complete safety information.